Quick Summary
Retatrutide is a triple agonist (GLP-1 + GIP + Glucagon), while Tirzepatide is dual (GLP-1 + GIP).
Retatrutide shows superior fat loss in trials — up to 24% total body weight vs 21% with Tirzepatide.
Both are long-acting and dosed weekly, but Retatrutide may offer greater energy expenditure and thermogenesis.
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