Quick Summary
- Retatrutide is a triple agonist peptide (GLP-1, GIP, Glucagon) under active investigation.
- Preclinical trials show dose-dependent fat loss, metabolic, and appetite-regulation benefits.
- Titration protocols start low (1mg) and increase gradually for best results.
- Peptides UK offers high-purity, COA-verified Retatrutide for research purposes only.
What Is Retatrutide and Why Dosage Matters
Retatrutide is a powerful investigational peptide designed to activate three hormonal receptors simultaneously. This multi-receptor approach impacts appetite, metabolism, insulin response, and fat oxidation.
Because of its potency and long-acting nature, most preclinical protocols use a titrated dosage approach — gradually increasing the dose over several weeks to reduce adverse reactions and optimize outcomes.
Source: Eli Lilly Phase 2 Trial (SURMOUNT-3)
Retatrutide Dosage Chart (Based on Preclinical Data)
| Week | Dose (mg/week) | Notes |
|---|---|---|
| 1–2 | 1.0 mg | Starting dose |
| 3–4 | 2.5 mg | Mild appetite suppression begins |
| 5–6 | 5.0 mg | Body fat and visceral loss increases |
| 7–8 | 7.5 mg | Enhanced metabolic response |
| 9–10 | 10.0 mg | Considered stable for most studies |
| 11–12 | 12.5 mg | Optional ramp for high BMI models |
| 13+ | 15.0 mg (max) | Maximum used in mouse/human trials |
Source: NEJM Study – Retatrutide for Obesity
Titration Guide: Best Practices
To replicate the safety-first model used in early-stage studies:
- Start at 1mg/week, even in high-BMI research models.
- Increase every 2–4 weeks, not faster.
- Observe tolerance and body composition indicators before adjusting.
- Avoid jumping to high doses — glucagon receptor activation can be intense.
⚠️ Note: Retatrutide is a research peptide and not approved for human use.
How to Reconstitute Retatrutide
Typical packaging: 20mg vial of lyophilized Retatrutide.
Reconstitution example:
- Add 2ml bacteriostatic water → concentration = 1mg = 0.1ml
- Dose 5mg = 0.5ml volume
- Store in refrigerator (2–8°C) after mixing
Retatrutide Research Outcomes by Dose Level
- 1–2.5mg: Appetite control, mild weight loss in obese mice
- 5–7.5mg: Significant visceral fat reduction, improved insulin sensitivity
- 10–15mg: Near-maximal fat loss; improved lipolysis and energy expenditure
This dose-dependent response is consistent with other GLP-1 family agonists, but Retatrutide’s glucagon activity makes titration essential.
Supporting Data: PubMed – Retatrutide Mechanisms
Buy Retatrutide With Verified COA
For researchers looking to study Retatrutide in controlled environments, Peptides UK offers:
- ✅ High-purity vials (≥99%)
- ✅ Full Certificates of Analysis
- ✅ Tracked UK & Ireland shipping
- ✅ Clear labelling for research use only
🧬 Buy Retatrutide from Peptides UK →
Frequently Asked Questions (FAQs)
What is the best starting dose for Retatrutide?
Most preclinical studies begin with 1mg per week, gradually increasing as tolerated.
How often should Retatrutide be dosed?
Retatrutide is a long-acting peptide and is usually dosed once weekly in studies.
What is the maximum dose used in studies?
15mg/week is the upper range used in advanced preclinical and early-phase clinical trials.
Disclaimer
This content is for educational and research purposes only. Retatrutide is not approved for human use. Outcomes are based on controlled lab research and may not translate to clinical application.
